2020.04 - 至今 安徽医科大学生命科学院，教授，博导，东南学者
2012.11 - 2019.12 美国贝勒医学院分子细胞系，博士后
2005.09 - 2012.07 中国科学院上海生物化学与细胞生物学研究所，博士
1998.09 - 2002.07 浙江大学生物科学与技术系，学士
本实验室长期的研究兴趣是肿瘤的发病机制和诊疗策略，致力于用动物模型，分子生物学，细胞生物学等手段，探索肿瘤发生的分子机制，寻找潜在的治疗靶点。目前的研究工作集中在两个方向：一是前列腺癌内分泌治疗耐受，探究相关的转录因子在去势抵抗性前列腺癌（CRPC，Castration resistant prostate cancer）和神经内分泌前列腺癌（NEPC, Neuroendocrine prostate cancer）进展中的作用和机制；二是肿瘤细胞的基因组不稳定性，主要以脑胶质瘤为模型，研究表观遗传失调如何影响染色体外环状DNA（ecDNA，Extrachromosomal circular DNA）的产生和功能，等等。
1. Mafei Xu, Jun Qin, Leiming Wang, Hui-Ju Lee, Chung-Yang Kao, Dan Liu, Zhou Songyang, Junjie Chen, Ming-Jer Tsai, and Sophia Y. Tsai. Nuclear receptors regulate alternative lengthening of telomeres through a novel non-canonical FANCD2 pathway. Sci. Adv. 2019; 5(10): eaax6366.
2. Chung-Yang Kao*, Mafei Xu*,, Leiming Wang*, Shih-Chieh Lin, Hui-Ju Lee,Lita Duraine, Hugo J. Bellen, David S. Goldstein, Sophia Y. Tsai, Ming-Jer Tsai. Elevated COUP-TFII expression in dopaminergic neurons accelerates the progression of Parkinson’s disease through mitochondrial dysfunction. PLOS Genetics. 2020; 16(6):e1008868.
3. Leiming Wang, Mafei Xu, Chung-Yang Kao, Sophia Y. Tsai, and Ming-Jer Tsai. JQ1 promotes prostate cancer invasion through FOXA1 inactivation in a BET protein-independent pathway. J Clin Invest. 2019; doi: 10.1172/JCI126327
4. Leiming Wang, Chiang-Min Cheng, Jun Qin, Mafei Xu, Chung-Yang Kao, Jingjing Shi, Erli You, Wanchun Gong, Laura Pedro Rosa, Peter Chase, Louis Scampavia, Franck Madoux, Timothy Spicer, Peter Hodder, H. Eric Xu, Sophia Y. Tsai, and Ming-Jer Tsai. The use of small molecule inhibitors targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment. Sci. Adv. 2020;6(18):eaaz8031
5. Hui-Ju Lee, Chung-Yang Kao, Shih-Chieh Lin, Mafei Xu, Xin Xie, Sophia Y. Tsai and Ming-Jer Tsai. Dysregulation of nuclear receptor COUP-TFII impairs skeletal muscle development. Sci Rep. 2017;7(1):3136.
6. Leiming Wang, Mafei Xu, Jun Qin, Shih-Chieh Lin, Hui-Ju Lee, Sophia Y. Tsai, and Ming-Jer Tsai. MPC1, a key gene in cancer metabo-lism, is regulated by COUPTFII in human prostate cancer. Oncotarget.2016;7(12):14673-83.
7. Mafei Xu, Jun Qin, Sophia Y. Tsai, and Ming-Jer Tsai. The role of the orphan nuclear receptor COUP-TFII in tumorigenesis. Acta Pharmacol Sin. 2015;36(1):32-6.
8. Daniëlle G.M. Bosch*, F. Nienke Boonstra*, Claudia Gonzaga-Jauregui*, Mafei Xu, Joep de Ligt, Shalini Jhangiani, Wojciech Wiszniewski, Donna M. Muzny, Helger G. Yntema, Rolph Pfundt, Lisenka E.L.M. Vissers, Liesbeth Spruijt, Ellen A.W. Blokland,Chun-An Chen, Baylor-Hopkins Center for Mendelian Genomics, Richard A. Lewis, Sophia Y. Tsai, Richard A. Gibbs, Ming-Jer Tsai, James R. Lupski, Huda Y. Zoghbi, Frans P.M. Cremers, Bert B.A. de Vries and Christian P. Schaaf. NR2F1 mutations cause optic atrophy with intellectual disability. Am J Hum Genet. 2014;94(2):303-9.
9. Mafei Xu, Fang Zhang, Liang Da, Tsaiping Li, Mujun Zhao. Microspherule protein 2 associates with ASK1 and acts as a negative regulator of stress-induced ASK1 activation. FEBS Lett. 2012;586(12):1678-86.
10. Guoyuan Chen, Liang Da, Ying Xu, Mafei Xu, Li Song, Tsaiping Li, Mujun Zhao. C-terminal amino acids 290-328 of LPTS/ PinX1 confer telomerase inhibition. Biochem Biophys Res Commun. 2010;398(4):683-9.
11. Chengfu Sun, Mafei Xu, Zhen Xing, Zhili Wu, Yiping Li, Tsaiping Li, Mujun Zhao. Expression and function on embryonic development of lissencephaly-1 genes in zebrafish. Acta Biochim Biophys Sin (Shanghai). 2009 Aug;41(8):677-88.
先锋转录因子GATA2调控IFN-β信号轴在前列腺癌内分泌治疗耐受中的功能及机制研究，国家自然科学基金委面上项目（项目编号：82073256），2021.1-2024.12，主持。
